January 2021 – Prof. Birkenfeld publishes new paper regarding the role of mIndy/NaCT for blood pressure titled „The longevity gene mIndy (I’m Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms.”

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Link to Paper

Eternygen GmbH Press release

Berlin, January 27, 2021

The longevity gene mINDY (I’m Not Dead, Yet) not only prevents metabolic disease, but also lowers arterial blood pressure and heart rate

Berlin, Germany, January 27,  2021 – Eternygen announces today the publication of Prof. Dr. Andreas Birkenfeld, one of Eternygen’s scientific founders in Journal of Clinical Investigation (JCI) Insight. He presented data showing that the longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation. Reduced expression of mINDY which is known to extend life span in lower organisms and to prevent from diet induced obesity, fatty liver and insulin resistance in mice,  has now been shown to lower blood pressure and heart rate in rodents. The authors provided mechanistic insights for the underlying physiological mechanism based on in vivo data in a genetic knock out model as well as microarray and in vitro studies. Furthermore, the hypothesis is supported by confirming critical effects in vitro using a small molecule inhibitor of mINDY. The authors conclude that deletion of mIndy recapitulates beneficial cardiovascular and metabolic responses to caloric restriction, making it an attractive therapeutic target.

Andreas Birkenfeld and colleagues provide a comprehensive study showing that mIndy deletion attenuates sympathoadrenal support of blood pressure and reduced arterial blood pressure and heart rate in a murine knockout model. Blood pressure was assessed invasively using intra-arterial pressure probes over several days. Urinary analysis for catecholamines and metanephrines as well as unbiased transcriptomic analysis of adrenal glands identified the affected biosynthetic pathways. Indeed, catecholamine biosynthesis was attenuated in mINDY-KO adrenals, whereas plasma steroids and steroid hormone synthesis were unaffected.

In vitro studies on an adrenal cell line supported this hypothesis. mIndy codes for a carboxylic acid transporter protein expressed in plasma membrane. Citrate, the main substrate of the mINDY transporter, increased catecholamine content, while pharmacological inhibition of mINDY by a small molecule inhibitor blunted the effect.

The study provided further insights into the physiological mechanisms of the beneficial effects of reducing mINDY activity which is known to protect from diet and aging induced metabolic diseases by mechanisms akin to caloric restriction. Therefore, the data showed a novel mechanism contributing to cardiometabolic cross talk and further supporting mINDY as a promising target for the whole spectrum of metabolic syndrome components, including increased blood pressure.

The study was published from the Institute of Diabetes Research and Metabolic Disorders (IDM) of the Helmholtz Center Munich at the University Tübingen and the Clinic of Diabetes, Endocrinology and Nephrology of the University Hospital Tübingen.

Publication:

Willmes DM, Daniels MA, Kurzbach A, Lieske S, Bechmann N, Schumann T, Henke C, El-Agroudy N, Da Costa Goncalves AC, Peitzsch M, Hofmann A, Kanczkowski W, Kräker K, Müller DN, Morawietz H, Deussen A, Wagner M, El-Armouche A, Helfand SL, Bornstein SR, de Cabo R, Bernier M, Eisenhofer G, Tank J, Jordan J, Birkenfeld AL. The longevity gene mIndy (I’m Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms. JCI Insight. 2021, doi.org/ 10.1172/jci.insight.136083

ABOUT ETERNYGEN GMBH

Eternygen is a Berlin-based Biotech Company founded in June 2012 to focus on the research, development and marketing of NaCT inhibitors for the treatment of dietary-related metabolic diseases. The founding team consists of renowned scientists from leading German universities and academic institutes as well as serial entrepreneurs from the venture and industry community. Eternygen is a virtual company supported by a network of senior industry experts and contract research organizations. Eternygen shareholders include Epidarex Capital, Evotec SE, VC Fonds Technologie, Berlin, Germany managed by IBB Venture, and two renowned family offices. For additional information please go to www.eternygen.com

CONTACT INFORMATION

Eternygen:
Marco Janezic, CEO. Ph. +49 30 1207 6983 – 0; email: m.janezic@eternygen.com
Dr. Grit Zahn, Head of Research. Ph. +49 30 1207 6983 – 1; email: g.zahn@eternygen.com

Prof. Birkenfeld publishes new review on Transporters as Drug Targets titled „Solute Carrier Transporters as Potential Targets for the Treatment of Metabolic Disease.”

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Prof. Birkenfeld publishes new review on Transporters as Drug Targets titled „Solute Carrier Transporters as Potential Targets for the Treatment of Metabolic Disease.”

Prof. Birkenfeld publishes new Review on Transporters as Drug Targets titled „Solute Carrier Transporters as Potential Targets for the Treatment of Metabolic Disease.”

Link to Paper

Prof. Birkenfeld publishes new review on NAFLD

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Prof. Birkenfeld publishes new review on NAFLD

(Link to Paper)

Prof. Birkenfeld in Sächsische Zeitung

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Prof. Birkenfeld in Sächsische Zeitung

Prof. Birkenfeld in Sächsische Zeitung with the topic “How your lifestyle advances diabetes”.

(Article in German)

Prof. Birkenfeld publishes new INDY (I’m Not Dead Yet) review

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Prof. Birkenfeld publishes new INDY (I’m Not Dead Yet) review

Prof. Birkenfeld publishes new INDY (I’m Not Dead Yet) review with the title  “The longevity gene INDY (I’m Not Dead Yet) in metabolic control: Potential as pharmacological target.”

(Article)

Prof. Birkenfeld visiting expert at MDR Sachsen radio

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Prof. Birkenfeld visiting expert at MDR Sachsen radio

Prof. Birkenfeld visiting expert at MDR Sachsen radio talking about cholesterol (in German)

Prof. Birkenfeld in expert discussion with MDR1 radio

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Prof. Birkenfeld in expert discussion with MDR1 radio

Discussion about “Sugar as a drug” (in German)

Prof. Birkenfeld in Sächsische Zeitung

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Prof. Birkenfeld in Sächsische Zeitung

Article about “the pill for a longer life” (in German)

Prof. Birkenfeld in an interview with “Der Tagesspiegel”

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Prof. Birkenfeld in an interview with “Der Tagesspiegel”

Interview about the topic “Healthy aging can be steered” (in German) 

Prof. Birkenfeld in an interview with Sächsische Zeitung

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Prof. Birkenfeld in an interview with Sächsische Zeitung

About the Topic: “Diabetes is avoidable” (in German)

Interview with Prof. Birkenfeld in “Faszination Wissen”

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Interview with Prof. Birkenfeld in “Faszination Wissen”

Interview part of the Episode about Immortality

Article (in German) 

Full Episode (in German) 

Interview with Prof. Birkenfeld in Die Zeit – Magazin

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Interview with Prof. Birkenfeld in Die Zeit – Magazin

Interview about the topic “The fat gene” (in German)

Interview with Prof. Birkenfeld in 3Sat – Nano

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Interview with Prof. Birkenfeld in 3Sat – Nano

Interview part of the Episode about “Sweet old age” (in German)

Interview with Prof. Jordan in the Ärztezeitung

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Interview with Prof. Jordan in the Ärztezeitung

Prof. Jordan about the topic „Heart hormones function like endurance training“ (in German)

Interview with Prof. Jordan in Hannoverschen Allgemeine

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Interview with Prof. Jordan in Hannoverschen Allgemeine

Prof. Jordan about the topic “Water keeps the circulation stable” (in German)

Prof Jordan about the topic „New blood pressure regulator identified after 60 years“ in Science Daily

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Prof Jordan about the topic „New blood pressure regulator identified after 60 years“ in Science Daily

In Science Daily of Helmholtz Association of German Research Centres. “Mediator of blood pressure regulation in the liver identified; Pressor reflex triggered simply by drinking water.”

Prof Jordan about the topic „New blood pressure regulator identified after 60 years“ in Science Daily”

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Prof Jordan about the topic „New blood pressure regulator identified after 60 years“ in Science Daily

In Science Daily of Helmholtz Association of German Research Centres. Mediator of blood pressure regulation in the liver identified; Pressor reflex triggered simply by drinking water.

Interview with Prof. Jordan in Hannoverschen Allgemeine

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Interview with Prof. Jordan in Hannoverschen Allgemeine

Prof. Jordan about the topic “Water keeps the circulation stable” (in German)